Dr. Stephan Schiffels

Dr. Stephan Schiffels

Department of Archaeogenetics
+49 3641 686-636

Main Focus

Leader of the Population Genetics Group

Homepage: http://www.stephanschiffels.de

Members: Thiseas Lamnidis (PhD student), Ke Wang (PhD student), Luka Papac (PhD student), Joscha Gretzinger (PhD student), Clemens Schmid (PhD student)

My research focuses on the analysis of human genome data, both from ancient human remains and from contemporary samples. An important part of my work consists of developing new methods to statistically analyze such data in order to reconstruct population history. This includes migration movements between regions and continents, the separation of people into spatially separated subpopulations, as well as changes in population size. By learning about these processes, we can ultimately draw conclusions about human history.

For a complete list of publications, see my Google Scholar page. I am also active on twitter and medium. All of the software that I develop can be found on Github.

Curriculum Vitae

I have studied Physics at the University of Cologne, Germany, and finished my PhD in January 2012. In my thesis I studied asexual adaptation and the effect of genetic linkage on natural selection. From 2012 until 2015 I was a Postdoctoral Fellow with Richard Durbin at the Wellcome Trust Sanger Institute in Hinton, Cambridge, UK. I have mainly worked on methods to estimate past demography from genome sequences, and on ancient DNA from archaeological sites in East England, dating to the Iron Age and early Anglo-Saxon era. Since September 2015 I am research group leader at the Max-Planck-Institute for the Science of Human History in Jena, Germany.

Since November 2019 I lead the EU Projekt MICROSCOPE, funded with 1.5 Million Euros by the European Research Council.

Selected Preprints

(Preprint) Tracking human population structure through time from whole genome sequences. Ke Wang, Iain Mathieson, Jared O’Connell, Stephan Schiffelsbiorxiv (2019) [Website] [PDF]

Selected Publications

For a complete list, see http://www.stephanschiffels.de/publications.html

Bookchapter "MSMC and MSMC2: The Multiple Sequentially Markovian Coalescent." Stephan Schiffels and Ke Wang. In "Statistical Population Genomics" (Springer), published January 24, 2020.

Paleo-Eskimo genetic ancestry and the peopling of Chukotka and North America. P Flegontov, NE Altinisik, P Changmai, N Rohland, S Mallick, N Adamski, DA Bolnick, N Broomandkhoshbacht, F Candilio, BJ Culleton, O Flegontova, TM Friesen, C Jeong, TK Harper, D Keating, DJ Kennett, AM Kim, TC Lamnidis, AM Lawson, I Olalde, J Oppenheimer, B Potter, J Raff, RA Sattler, P Skoglund, K Stewardson, EJ Vajda, S Vasilyev, E Veselovskaya, MG Hayes, DH O’Rourke, J Krause, R Pinhasi, D Reich, S SchiffelsNature (2019) [Website]

Ancient Fennoscandian genomes reveal origin and spread of Siberian ancestry in Europe. TC Lamnidis, K Majander, C Jeong, E Salmela, A Wessman, V Moiseyev, V Khartanovich, O Balanovsky, M Ongyerth, A Weihmann, A Sajantila, J Kelso, S Pääbo, P Onkamo, W Haak, J Krause, S SchiffelsNature Communications (2018) [Website] [PDF]

Möglichkeiten und Grenzen molekulargenetischer Untersuchungen in den Geschichtswissenschaften. W Haak, S Schiffels. N.T.M. Zeitschrift für Geschichte der Wissenschaften, Technik und Medizin (2018) [Website] [PDF]

The genetic prehistory of the Baltic Sea region. A Mittnik, CC Wang, S Pfrengle, M Daubaras, G Zariņa, F Hallgren, R Allmäe, V Khartanovich, V Moiseyev, A Furtwängler, A Andrades Valtueña, M Feldman, C Economou, M Oinonen, A Vasks, M Tõrv, O Balanovsky, D Reich, R Jankauskas, W Haak, S Schiffels, J Krause. Nature Communications (2018) [Website] [PDF]

Investigating Anglo-Saxon migration history with ancient and modern DNA. S Schiffels, D Sayer: Tagungen Des Landesmuseums Für Vorgeschichte Halle(2017) [PDF]

Ancient Egyptian mummy genomes suggest an increase of Sub-Saharan African ancestry in post-Roman periods. VJ Schuenemann, A Peltzer, B Welte, WP van Pelt, M Molak, CC Wang, A Furtwängler, C Urban, E Reiter, K Nieselt, B Teßmann, M Francken, K Harvati, W Haak, S Schiffels, J Krause. Nature communications (2017) [Website] [PDF]

A genomic history of Aboriginal Australia. AS Malaspinas, MC Westaway, CMuller, VC Sousa, O Lao, I Alves, A Bergström, G Athanasiadis, JY Cheng, JE Crawford, TH Heupink, E Macholdt, S Peischl, S Rasmussen, S Schiffels, et al. Nature (2016) [Website]

Iron age and Anglo-Saxon genomes from East England reveal British migration history. S Schiffels, W Haak, P Paajanen, B Llamas, E Popescu, L Loe, R Clarke, A Lyons, R Mortimer, D Sayer, C Tyler-Smith, A Cooper, R Durbin: Nature communications (2016) [Website] [PDF]

Genomic evidence for the Pleistocene and recent population history of Native Americans. M Raghavan, M Steinrücken, K Harris, S Schiffels, S Rasmussen, M DeGiorgio, A Albrechtsen, C Valdiosera, MC Ávila-Arcos, AS Malaspinas, et al. Science (2015) [Website]

Tracing the route of modern humans out of Africa by using 225 human genome sequences from Ethiopians and Egyptians. L Pagani, S Schiffels, D Gurdasani, P Danecek, A Scally, et al. The American Journal of Human Genetics (2015) [Website] [PDF]

Inferring human population size and separation history from multiple genome sequences. S Schiffels, R Durbin. Nature Genetics (2014) [Website]

Emergent neutrality in adaptive asexual evolution. S Schiffels, GJ Szöllősi, V Mustonen, M Lässig. Genetics (2011) [Website] [PDF]

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